Skip to main content
. Author manuscript; available in PMC: 2026 Aug 2.
Published in final edited form as: J Autoimmun. 2026 Jul 20;163:103597. doi: 10.1016/j.jaut.2026.103597

Figure 3. NC-TAC enhances Treg suppressive function in AIH.

Figure 3.

Treg cells, isolated from the peripheral blood of HS and AIH patients were tested for their ability to proliferate in the presence of Dynabeads Human T activator CD3/CD28 and IL-2, following exposure to vehicle, NC, NC-TAC or unencapsulated TAC. (A) Violin plots showing the absorbance at 490 nm of Tregs in the presence of vehicle, NC, NC-TAC or TAC (HS, n=16; AIH, n=9). Treg suppression was measured as percentage inhibition of CD4+CD25− cell proliferation. (B) Violin plots representing the percentage inhibition of CD4+CD25− cell proliferation following co-culture with Tregs exposed to vehicle, NC, NC-TAC or TAC (HS, n=6; AIH, n=5). *P≤0.05; **P≤0.01 (one-way ANOVA test followed by Tukey’s multiple comparisons test). In each violin plot, median and quartiles are shown. Exposure to NC-TAC enhances AIH Treg suppressive function.