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. Author manuscript; available in PMC: 2006 Jan 20.
Published in final edited form as: Biochemistry. 2005 Oct 25;44(42):13902–13913. doi: 10.1021/bi0509346

Fig. 9.

Fig. 9

Effect of bromocriptine on the kinetics of reduction of the total pool (a) and the high-spin fraction (b) of CYP3A4 incorporated into the lipid-rich proteoliposomes (Sample II). Kinetic curves were recorded at no substrate added (circles) and in the presence of 8 μM (squares), 16 μM (triangles) and 32 μM (diamonds) bromocriptine. The data are plotted in semilogarithmic coordinates. Lines show the results of fitting of the data to the equation of sum of two exponents (a) or mono-exponential equation (b). Reaction mixture contained 3 μM of CYP3A4 in lipid-rich liposomes (Sample II). Other conditions as indicated in Fig. 3.