Table 1.
Mutation of Atoh1, Neurog1 and double Atoh1/Neurog1 affect the size and length of cochlea and anterior crista as judged by measuring the area of Bdnf expression or total length.
| Cochlea | WT | Atoh1 null | Atoh1/WT % of length | Neurog1null | Neurog1/WT % of length | Atoh1-Neurog1double null | Atoh1-Neurog1/WT % of length |
|---|---|---|---|---|---|---|---|
| Bdnf (μm) | 5495+/−68 | 3722+/− 37 | 68% | 2356+/−29 | 42% | 1329+/−18 | 24% |
| Total (μm) | 5776+/−86 | 5407+/−78 | 93% | 3083+/−48 | 53% | 3003+/−76 | 52% |
| Anterior crista | |||||||
| Width (μm) | 237+/−21 | 125+/−19 | 53% | 193+/−44 | 81% | 79+/−32 | 33% |
| Length (μm) | 608+/−35 | 451+/−38 | 74% | 413+/−35 | 68% | 225+/−86 | 37% |
| Area (μm2) | 107350+/−193 | 36487+/−283 | 34% | 58003+/−175 | 54% | 12755+/−88 | 12% |
| N=6 | N=6 | N=4 | N=4 | ||||