TABLE 3.
Total glutathione and reduced glutathione concentrations in liver and spleen of mice at 20 h after intraperitoneal injection of LPS (5 × 106 EU/kg) or vehicle (5 ml phosphate-buffered saline/kg)1
| Slc23a2 genotype | Treatment | Total glutathione in liver (nmol/mg) | Reduced glutathione in liver (nmol/mg) | Total glutathione in spleen (nmol/mg) | Reduced glutathione in spleen (nmol/mg) |
|---|---|---|---|---|---|
| +/+ | Vehicle | 7.38 ± 0.33 | 6.98 ± 0.34 | 2.79 ± 0.13 | 2.49 ± 0.16 |
| +/+ | LPS | 7.61 ± 0.49 | 7.12 ± 0.49 | 2.64 ± 0.23 | 2.46 ± 0.24 |
| +/− | Vehicle | 8.07 ± 0.62 | 7.70 ± 0.56 | 3.09 ± 0.11 | 2.76 ± 0.09 |
| +/− | LPS | 7.07 ± 0.55 | 6.74 ± 0.52 | 2.93 ± 0.11 | 2.60 ± 0.11 |
| P-value2 | |||||
| Genotype | 0.9 | 0.7 | 0.2 | 0.1 | |
| LPS | 0.4 | 0.4 | 0.5 | 0.3 | |
1
Values are means ± SEM, n = 5–7.
2
Differences between means were evaluated by 2-way ANOVA. There were no genotype × LPS interactions.