Table 2.
Uni-/multivariate logistic regression analysis of clinical data
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| P | OR (95%CI) | P | OR (95%CI) | |
| Age (y) | 0.810 | 0.99 (0.95 ~ 1.04) | ||
| Tumor maximum diameter (mm) | 0.026 | 0.98 (0.97 ~ 0.99) | 0.036 | 0.92 (0.86 ~ 0.99) |
| NEU% | 0.781 | 0.98 (0.82 ~ 1.17) | ||
| LYM% | 0.630 | 1.21 (0.56 ~ 2.58) | ||
| MONO% | 0.168 | 0.25 (0.04 ~ 1.79) | ||
| NLR | 0.600 | 1.03 (0.93 ~ 1.13) | ||
| PLR | 0.766 | 1.00 (1.00 ~ 1.01) | ||
| LMR | 0.099 | 1.39 (0.94 ~ 2.07) | 0.216 | 1.97 (0.67 ~ 5.77) |
| Total bilirubin (µmol/L) | 0.182 | 1.05 (0.98 ~ 1.13) | 0.034 | 1.12 (1.01 ~ 1.24) |
| ALB (g/L) | 0.316 | 0.96 (0.88 ~ 1.04) | ||
| ALT (U/L) | 0.601 | 1.00 (1.00 ~ 1.00) | ||
| AST (U/L) | 0.290 | 1.00 (1.00 ~ 1.01) | ||
| GGT (U/L) | 0.738 | 1.00 (0.99 ~ 1.00) | ||
| ALP (U/L) | 0.582 | 1.00 (0.98 ~ 1.01) | ||
| T cell | 0.545 | 0.97 (0.87 ~ 1.07) | ||
| CD4+ T cell | 0.074 | 0.90 (0.81 ~ 1.01) | 0.191 | 0.88 (0.74 ~ 1.06) |
| CD8+ T cell | 0.950 | 1.00 (0.92 ~ 1.09) | ||
| AFP | ||||
| ﹥ 400 ng/ml | 1.00 (Reference) | |||
| >400 ng/ml | 0.836 | 1.13 (0.37 ~ 3.44) | ||
| PIVKA-II | ||||
| ≤ 40 mAU/ml | 1.00 (Reference) | |||
| ﹥40 mAU/ml | 0.694 | 1.25 (0.41 ~ 3.80) | ||
| CA199 | ||||
| ≤ 37 U/ml | 1.00 (Reference) | |||
| ﹥37 U/ml | 0.753 | 1.21 (0.37 ~ 4.02) | ||
| CEA | ||||
| ≤ 5 ng/ml | 1.00 (Reference) | |||
| ﹥5 ng/ml | 0.522 | 0.47 (0.05 ~ 4.82) | ||
| Hepatitis B virus | ||||
| No | 1.00 (Reference) | |||
| Yes | 0.812 | 1.18 (0.31 ~ 4.49) | ||
Abbreviations: cHCC-CCA combined hepatocellular carcinoma-cholangiocarcinoma, NEU% Neutrophil granulocytes ratio, LYM% Lymphocyte ratio, MONO% Monocyte ratio, NLR Neutrophil/lymphocyte ratio, PLR Platelet/lymphocyte ratio, LMR Lymphocyte/monocyte ratio, ALB Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-Glutamyl transferase, ALP Alkaline phosphatase, AFP Alpha-fetoprotein, PIVKA-II Protein induced by vitamin K absence or antagonist-Il, CA199 Carbohydrate antigen 199, CEA Carcinoembryonic antigen
P < 0.05 was considered statistically significant