Table 3.
Outcome | Slidenafil n = 7077 | Tadalafil n = 2036 | Vardenafil n = 3274 |
Efficacy | |||
Improved erections | 83 | 83 | 100 |
Mean # erections/week | 20 | 0 | 0 |
Successful attempts at SI | 47 | 72 | 100 |
More than 60/75% successful | 10 | 0 | 18 |
More than 40% successful | 0 | 0 | 0 |
Final score IIEF Q3 | 94 | 27 | 26 |
Mean change IIEF Q3 | 91 | 27 | 26 |
Final score IIEF Q4 | 94 | 27 | 26 |
Mean change IIEF Q4 | 91 | 27 | 26 |
Final score EF Domain | 56 | 72 | 100 |
Mean change EF Domain | 54 | 83 | 77 |
Normal EF at endpoint | 8 | 56 | 14 |
Withdrawals | |||
All-cause | 83 | 65 | 69 |
Lack of efficacy | 81 | 72 | 82 |
Adverse event | 90 | 83 | 100 |
Adverse events | |||
Men with any adverse event | 42 | 40 | 18 |
Severe | 27 | 25 | 35 |
Serious | 38 | 83 | 78 |
Treatment related | 55 | 3 | 43 |
Headache | 99 | 90 | 86 |
Dyspepsia | 79 | 71 | 73 |
Flushing | 99 | 73 | 73 |
Nasal congestion/rhinitis | 64 | 35 | 73 |
Visual disturbances | 89 | 46 | 55 |
Back pain | 13 | 73 | 9 |
Myalgia/increased CPK | 16 | 60 | 18 |
Flu syndrome | 17 | 30 | 34 |
CV events | 24 | 27 | 33 |
Limb pain | 10 | 11 | 0 |
Fatigue | 3 | 15 | 0 |
Priapism | 29 | 0 | 0 |
Nausea | 14 | 0 | 0 |