Abstract
The mechanism of protamine-induced hypotension and bradycardia was investigated in anesthetized, heparinized dogs. Several groups of animals with intact circulation were studied for their responses to protamine under control conditions and following the administration of various pharmacological agents. The parameters observed include femoral arterial pressure (FAP), central venous pressure (CVP), left ventricular pressure (LVP) and its rate of rise (dp/dt), left ventricular contractile element velocity of shortening (Vce), maximal Vce (V max) and cardiac output (CO). Various groups were studied under the following pharmacological conditions: autonomic cholinergic blockade by atropine; alpha and beta adrenergic receptor blockade using phenoxybenzamine and propranolol respectively; ganglionic and adrenal medullary block using hexamethonium, and depletion of endogenous histamine by means of compound 48/80. Another group was placed on total cardiopulmonary bypass thus isolating the heart from the peripheral circulation. The effect of protamine on the vascular tree alone was then observed by monitoring FAP before and after protamine administration. The findings indicate that the cardiovascular effects of protamine are produced by a direct effect on the myocardium and vascular tree.
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Selected References
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- EGERTON W. S., ROBINSON C. L. The anti-heparin, anticoagulant and hypotensive properties of hexadimethrine and protamine. Lancet. 1961 Sep 16;2(7203):635–637. doi: 10.1016/s0140-6736(61)90311-7. [DOI] [PubMed] [Google Scholar]
- GERBODE F., HURT R., OSBORN J. J., PERKINS H. A. The neutralization of heparin by protamine in extracorporeal circulation. J Thorac Surg. 1956 Nov;32(5):612–619. [PubMed] [Google Scholar]
- Goldman B. S., Joison J., Austen W. G. Cardiovascular effects of protamine sulfate. Ann Thorac Surg. 1969 May;7(5):459–471. doi: 10.1016/s0003-4975(10)66210-8. [DOI] [PubMed] [Google Scholar]
- Gourin A., Streisand R. L., Greineder J. K., Stuckey J. H. Protamine sulfate administration and the cardiovascular system. J Thorac Cardiovasc Surg. 1971 Aug;62(2):193–204. [PubMed] [Google Scholar]
- Gourin A., Streisand R. L., Stuckey J. H. Total cardiopulmonary bypass, myocardial contractility, and the administration of protamine sulfate. J Thorac Cardiovasc Surg. 1971 Jan;61(1):160–166. [PubMed] [Google Scholar]
- MINKER E., KOLTAI M. EFFECT OF PROTAMINE SULPHATE ON THE TRANSMISSION PROCESSES IN PERIPHERAL SYMPATHETIC GANGLIA. Acta Physiol Acad Sci Hung. 1964;24:365–371. [PubMed] [Google Scholar]
- Mason D. T., Spann J. F., Jr, Zelis R. Quantification of the contractile state of the intact human heart. Maximal velocity of contractile element shortening determined by the instantaneous relation between the rate of pressure rise and pressure in the left ventricle during isovolumic systole. Am J Cardiol. 1970 Sep;26(3):248–257. doi: 10.1016/0002-9149(70)90791-5. [DOI] [PubMed] [Google Scholar]
- PAPACOSTAS C. A., LOEW E. R., WEST G. B. Studies on the toxicology of a histamine liberator, compound 48-80. Arch Int Pharmacodyn Ther. 1959 Jul 1;120:353–362. [PubMed] [Google Scholar]
- PATON W. D. M. Compound 48/80: a potent histamine liberator. Br J Pharmacol Chemother. 1951 Sep;6(3):499–508. doi: 10.1111/j.1476-5381.1951.tb00661.x. [DOI] [PMC free article] [PubMed] [Google Scholar]