TABLE 4.

Comparison of gene mutation features between two groups.

Indicator	Benign group (n = 128)	Malignant group (n = 84)	Statistics	P value
Overall mutation detection rate (%, x̄±s)	2.84 ± 0.52	2.18 ± 0.63	t = −8.142	<0.001
Pathogenic/likely pathogenic variant rate (RPK, x̄±s)	45.6 ± 8.3	36.2 ± 9.5	t = −7.524	<0.001
VUS variant rate (RPK, x̄±s)	38.2 ± 6.7	36.8 ± 7.2	t = −1.432	0.154
Mutation allele frequency—driver genes (RPK) [M(Q1,Q3)]	42.5 (35.2,51.8)	32.6 (26.4,40.3)	Z = −6.235	<0.001
GMS (x̄±s)	1.82 ± 0.68	0.95 ± 0.74	t = −8.756	<0.001