TABLE 7.
Spearman correlation analysis between gene mutation indicators and clinicopathological parameters.
| Indicator | TMB | Overall mutation detection rate | Driver gene MAF | GMS |
|---|---|---|---|---|
| Age | 0.245** | −0.198** | −0.156* | −0.187** |
| Tumor size | 0.412*** | −0.367*** | −0.328*** | −0.392*** |
| BI-RADS classification | 0.386*** | −0.358*** | −0.342*** | −0.425*** |
| CA15-3 | 0.358*** | −0.312*** | −0.289*** | −0.334*** |
| CEA | 0.341*** | −0.298*** | −0.276*** | −0.318*** |
| Histological grade(a) | 0.338*** | −0.324*** | −0.298*** | −0.356*** |
| Overall mutation detection rate | −0.524*** | 1 | 0.612*** | 0.658*** |
| Driver gene MAF | −0.468*** | 0.612*** | 1 | 0.584*** |
| GMS | −0.498*** | 0.658*** | 0.584*** | 1 |
*P < 0.05, **P < 0.01, ***P < 0.001; (a) Analysis performed only for 84 malignant cases; after Bonferroni correction (α = 0.0017), marked correlations remain statistically significant.