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. 2026 Jul 22;17:1898027. doi: 10.3389/fendo.2026.1898027

Table 6.

Cycle cancellation rates by risk group and estradiol exposure duration.

Risk groups Short (8–9 days) exposure Intermediate (10–11 days) exposure Prolonged (12–14 days) exposure Overall
DOR 13/133 9.8% (5.3-16.1) 18/96 18.8% (11.5-28) 6/31 19.4% (7.5-37.5) 37/260 14.2% (10.2-19.1)
NNS 10 (6-19) 5 (4-9) 5 (3-13) 7 (5-10)
Age >37 6/77 7.8% (2.9-16.2) 9/47 19.1% (9.1-33.3) 5/18 27.8% (9.7-53.5) 20/142 14.1% (8.8-20.9)
NNS 13 (6-34) 5 (3-11) 4 (2-10) 7 (5-11)
DOR + Age >37 6/42 14.3% (5.4-28.5) 9/29 31.0% (15.3-50.8) 4/8 50.0% (15.7-84.3) 19/79 24.1% (15.1-35)
NNS 7 (4-18) 3 (2-7) 2 (1-6) 4 (3-7)
Normal reserve 7/468 1.5% (0.6-3.1) 9/346 2.6% (1.2-4.9) 9/142 6.3% (2.9-11.7) 25/956 2.6% (1.7-3.8)
NNS 67 (33-166) 38 (20-84) 16 (9-34) 38 (26-59)
PCOS 1/379 0.3.% (0.0-1.5) 2/304 0.7% (0.1-2.4) 1/102 1.0% (0.0-5.3) 4/785 0.5% (0.1-1.3)
NNS 379 (68-14970) 152 (42-1254) 102 (19-4029) 196 (77-719)

Values are presented as n/N, percentages (95% CI), or estimates (95% CI).

NNS, number needed to screen to detect one progesterone-related cancellation.

DOR, diminished ovarian reserve; PCOS, polycystic ovary syndrome.