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. 2026 Jul 22;16:1883622. doi: 10.3389/fonc.2026.1883622

Table 4.

Exploratory risk stratification based on internally cross-validated predicted probabilities.

Risk category Probability
range
Patients,
n (%)
CSPCa
cases, n
CSPCa detection rate,
% (95% CI)
Low risk <0.20 136 (70.5) 11 8.1 (4.6-13.9)
Intermediate risk 0.20-0.70 39 (20.2) 15 38.5 (24.9-54.1)
High risk ≥0.70 18 (9.3) 15 83.3 (60.8-94.2)

Risk categories were based on 5-fold internally cross-validated predicted probabilities from the final logistic regression model, with feature selection embedded within each training fold and the displayed final predictors given as age, PHI, and PHID. Confidence intervals were calculated using the Wilson method. These thresholds are exploratory probability bands and should not be interpreted as externally validated clinical decision cutoffs. CSPCa, clinically significant prostate cancer; CI, confidence interval; PHI, Prostate Health Index; PHID, PHI density.