Abstract
Effects of intermittent (IPPB) and positive eng-expiratory pressure (PEEP) ventilation on accumulation of pulmonary edema were compared, in dogs, after infusion of oleic acid. Pulmonary extravascular water was approximated as lung thermal volume (LTV), a double indicator method based on differential transit time for simultaneously injected right-to-left conductivity and thermal pulses. LTV was found to be decreased in animals treated with PEEP. The possibility that observed LTV changes reflect only the effect of PEEP on flow distribution, not lung water, was examined by alternating PEEP and IPPB; short-term changes in LTV did not occur. Mean values of other factors influencing pulmonary water transfer, e.g., pulmonary capillary wedge pressure, serum protein, arterial blood gasses, were not significantly different with or without PEEP. It was concluded that, for the oleic acid lesion, PEEP effects a small reduction in the rate of accumulation of pulmonary edema.
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Selected References
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- Alexander L. G., DeVries W. C., Anderson R. W. Airway pressure and pulmonary edema formation. Surg Forum. 1973;24:231–234. [PubMed] [Google Scholar]
- CHINARD F. P., ENNS T., NOLAN M. F. Indicator-dilution studies with "diffusible" indicators. Circ Res. 1962 Mar;10:473–490. doi: 10.1161/01.res.10.3.473. [DOI] [PubMed] [Google Scholar]
- Demling R. H., Edmunds L. H., Jr Effect of continuous positive airway pressure on extravascular lung water. Surg Forum. 1973;24:226–228. [PubMed] [Google Scholar]
- GUYTON A. C. A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circ Res. 1963 Apr;12:399–414. doi: 10.1161/01.res.12.4.399. [DOI] [PubMed] [Google Scholar]
- Levine O. R., Mellins R. B., Senior R. M., Fishman A. P. The application of Starling's law of capillary exchange to the lungs. J Clin Invest. 1967 Jun;46(6):934–944. doi: 10.1172/JCI105599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Noble W. H., Severinghaus J. W. Thermal and conductivity dilution curves for rapid quantitation of pulmonary edema. J Appl Physiol. 1972 Jun;32(6):770–775. doi: 10.1152/jappl.1972.32.6.770. [DOI] [PubMed] [Google Scholar]
- Staub N. C., Nagano H., Pearce M. L. Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs. J Appl Physiol. 1967 Feb;22(2):227–240. doi: 10.1152/jappl.1967.22.2.227. [DOI] [PubMed] [Google Scholar]
- Uzawa T., Ashbaugh D. G. Continuous positive-pressure breathing in acute hemorrhagic pulmonary edema. J Appl Physiol. 1969 Apr;26(4):427–432. doi: 10.1152/jappl.1969.26.4.427. [DOI] [PubMed] [Google Scholar]