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. 1974 Oct;180(4):402–406. doi: 10.1097/00000658-197410000-00004

Chronic Tissue Insulin Resistance Following Hemorrhagic Shock

N Thomas Ryan, Barbara C George, David H Egdahl, Richard H Egdahl
PMCID: PMC1344109  PMID: 4412446

Abstract

Metabolism of fat and muscle tissue was measured for 30 days following shock and reinfusion in rabbits. Tissue insulin resistance in the post-shock period was demonstrated by decreased oxidation of glucose and decreased incorporation of glucose into neutral lipid or glycogen during incubation with insulin. In addition, the insulin stimulated incorporation of amino acids into muscle protein was markedly reduced after shock. Conversely, the capacity of muscle to oxidize leucine was enhanced by shock, even in the presence of insulin. Tissue insulin resistance and increased leucine catabolism are likely to contribute to the general metabolic response to shock and trauma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blockwood J. M., Hsieh J., Fewel J., Rush B. F., Jr Tissue metabolites in endotoxin and hemorrhagic shock; a comparison. Arch Surg. 1973 Aug;107(2):181–185. doi: 10.1001/archsurg.1973.01350200055014. [DOI] [PubMed] [Google Scholar]
  2. Buse M. G., Biggers J. F., Drier C., Buse J. F. The effect of epinephrine, glucagon, and the nutritional state on the oxidation of branched chain amino acids and pyruvate by isolated hearts and diaphragms of the rat. J Biol Chem. 1973 Jan 25;248(2):697–706. [PubMed] [Google Scholar]
  3. Cahill G. F., Jr, Aoki T. T. How metabolism affects clinical problems. Med Times. 1970 Oct;98(10):106–122. [PubMed] [Google Scholar]
  4. Cahill G. F., Jr The Banting Memorial Lecture 1971. Physiology of insulin in man. Diabetes. 1971 Dec;20(12):785–799. doi: 10.2337/diab.20.12.785. [DOI] [PubMed] [Google Scholar]
  5. Chansouria J. P., Singh A. K., Udupa K. N. Studies on plasma insulin levels in the posttraumatic phase in rabbits. J Trauma. 1973 Dec;13(12):1063–1065. doi: 10.1097/00005373-197312000-00004. [DOI] [PubMed] [Google Scholar]
  6. Cuthbertson D. P., Tilstone W. J. Nutrition of the injured. Am J Clin Nutr. 1968 Sep;21(9):911–922. doi: 10.1093/ajcn/21.9.911. [DOI] [PubMed] [Google Scholar]
  7. DRUCKER W. R., DEKIEWIET J. C. GLUCOSE UPTAKE BY DIAPHRAGMS FROM RATS SUBJECTED TO HEMORRHAGIC SHOCK. Am J Physiol. 1964 Feb;206:317–320. doi: 10.1152/ajplegacy.1964.206.2.317. [DOI] [PubMed] [Google Scholar]
  8. HAYES M. A., BRANDT R. L. Carbohydrate metabolism in the immediate postoperative period. Surgery. 1952 Nov;32(5):819–827. [PubMed] [Google Scholar]
  9. HOWARD J. M. Studies of the absorption and metabolism of glucose following injury; the systemic response to injury. Ann Surg. 1955 Mar;141(3):321–326. doi: 10.1097/00000658-195503000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haljamäe H. Effects of hemorrhagic shock and treatment with hypothermia on the potassium content and transport of single mammalian skeletal muscle cells. Acta Physiol Scand. 1970 Feb;78(2):189–200. doi: 10.1111/j.1748-1716.1970.tb04655.x. [DOI] [PubMed] [Google Scholar]
  11. Haljamäe H. Potassium transport in single mammalian skeletal muscle cells during in vitro incubation. Acta Physiol Scand. 1970 Feb;78(2):201–212. doi: 10.1111/j.1748-1716.1970.tb04656.x. [DOI] [PubMed] [Google Scholar]
  12. Hiebert J. M., Celik Z., Soeldner J. S., Egdahl R. H. Insulin response to hemorrhagic shock in the intact and adrenalectomized primate. Am J Surg. 1973 Apr;125(4):501–507. doi: 10.1016/0002-9610(73)90090-1. [DOI] [PubMed] [Google Scholar]
  13. Holm J., Scherstén T. In vitro metabolism of glucose by human skeletal muscle. Method and normal values. Scand J Clin Lab Invest. 1972 Feb;29(1):99–107. doi: 10.3109/00365517209081061. [DOI] [PubMed] [Google Scholar]
  14. King L. R., Knowles H. C., Jr, McLaurin R. L., Lewis H. P. Glucose tolerance and plasma insulin in cranial trauma. Ann Surg. 1971 Mar;173(3):337–343. doi: 10.1097/00000658-197103000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kitabchi A. E., Duckworth W. C., Benson B. In vivo effects of insulin and proinsulin on diaphragm and epididymal fat pads in rats. Diabetes. 1972 Sep;21(9):935–938. doi: 10.2337/diab.21.9.935. [DOI] [PubMed] [Google Scholar]
  16. Lindseth R. E. Postoperative glucose metabolism in diabetic and nondiabetic patients. The response of glucose, insulin, growth hormone, corticosteroids, epinephrine, and unesterified fatty acids to extremity surgery. Arch Surg. 1972 Nov;105(5):741–745. doi: 10.1001/archsurg.1972.04180110064016. [DOI] [PubMed] [Google Scholar]
  17. OLSEN N. S., NUETZEL J. A. Resistance to small doses of insulin in various clinical conditions. J Clin Invest. 1950 Jul;29(7):862–866. doi: 10.1172/JCI102319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Odessey R., Goldberg A. L. Oxidation of leucine by rat skeletal muscle. Am J Physiol. 1972 Dec;223(6):1376–1383. doi: 10.1152/ajplegacy.1972.223.6.1376. [DOI] [PubMed] [Google Scholar]
  19. RIDDICK F. A., Jr, REISLER D. M., KIPNIS D. M. The sugar transport system in striated muscle. Effect of growth hormone, hydrocortisone and alloxan diabetes. Diabetes. 1962 May-Jun;11:171–178. [PubMed] [Google Scholar]
  20. Ross H., Johnston I. D., Welborn T. A., Wright A. D. Effect of abdominal operation on glucose tolerance and serum levels of insulin, growth hormone, and hydrocortisone. Lancet. 1966 Sep 10;2(7463):563–566. doi: 10.1016/s0140-6736(66)93036-4. [DOI] [PubMed] [Google Scholar]
  21. Skillman J. J., Hedley-Whyte J., Pallotta J. A. Cardiorespiratory, metabolic and endocrine changes after hemorrhage in man. Ann Surg. 1971 Dec;174(6):911–922. doi: 10.1097/00000658-197112000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Skillman J. J., Lauler D. P., Hickler R. B., Lyons J. H., Olson J. E., Ball M. R., Moore F. D. Hemorrhage in normal man: effect on renin, cortisol, aldosterone, and urine composition. Ann Surg. 1967 Dec;166(6):865–885. doi: 10.1097/00000658-196712000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. WOOL I. G. Incorporation of C14-amino acids into protein of isolated diaphragms: effect of epinephrine and norepinephrine and norepinephrine. Am J Physiol. 1960 Jan;198:54–56. doi: 10.1152/ajplegacy.1960.198.1.54. [DOI] [PubMed] [Google Scholar]
  24. WOOL I. G., WEINSHELBAUM E. I. Incorporation of C14-amino acids into protein of isolated diaphragms: role of the adrenal steroids. Am J Physiol. 1959 Nov;197:1089–1092. doi: 10.1152/ajplegacy.1959.197.5.1089. [DOI] [PubMed] [Google Scholar]

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