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. 1976 Jul;184(1):97–102. doi: 10.1097/00000658-197607000-00016

Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide (GIP) and vasoactive intestinal polypeptide (VIP).

H V Villar, H R Fender, P L Rayford, S R Bloom, N I Ramus, J C Thompson
PMCID: PMC1344314  PMID: 938120

Abstract

Five dogs prepared with Heidenhain pouches received infusions of saline, GIP and VIP before and after a standard meat meal. Blood samples were obtained under basal conditions and at subsequent intervals for measurement of gastrin, insulin, GIP and VIP by radioimmunoassay. GIP and VIP infusions had no effect on basal levels of gastrin. GIP and VIP (in common with secretin and glucagon) were found to suppress food-stimulated release of gastrin and gastrin-stimulated acid secretion from the Heidenhain pouch. Insulin levels were significantly elevated during GIP and VIP infusions. Food released GIP (and perhaps VIP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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