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. 2026 Jul 24;29(8):116870. doi: 10.1016/j.isci.2026.116870

Figure 2.

Figure 2

Annotated B cell subpopulations in CanL exhibit minimal frequency change but marked transcriptional shifts during progression

(A) UMAP visualization of 11 B cell subclusters. The inset shows the projection of these cells onto the PBMC UMAP.

(B) UMAP visualization of 8 annotated populations of B cells.

(C) Dot plot shows canonical marker gene expression and proportions in B cell subclusters (LOC100685971: IGHM).

(D) Bar plot depicts the proportion of cells across CanL clinical stages, colored by B cell population. See also Table S2.

(E) Heatmap visualization of top 50 differentially expressed genes (DEGs) of each annotated B cell subcluster. DEGs and subclusters arranged by hierarchical clustering. Highlighted DEGs correspond to those visualized in Figure 2F. See also Table S4.

(F) Dot plot shows expression and proportions within specific cell populations of curated gene sets across CanL clinical stages.

(G) Heatmap of average expression for genes associated with inflammation and immunoregulation across B cell major subpopulations and CanL clinical stages.