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. 2002 Sep 19;3(10):research0052.1–research0052.18. doi: 10.1186/gb-2002-3-10-research0052

Table 2.

TSD sequences are A-rich

TSD composition Observed* Expected
0-10% As 0.1% 2.7%
10-20% As 2.5% 26.6%
20-30% As 8.6% 23.8%
30-40% As 31.5% 36.8%
40-50% As 18.0% 7.4%
50-60% As 28.5% 2.7%
60-70% As 5.2% 0.1%
Over 70% As 5.5% 0.0%

*TSDs of length 15 nucleotides without mismatches were classified according to their A content. Monte Carlo simulation was used to generate random 15-nucleotide sequences representative of the nucleotide population of the human genome. Only 10% of these randomly generated sequences were equal to or greater than the average A content of the TSDs.