Figure 1.
(A) Flow diagram of the Zhejiang Colorectal Cancer Screening Program. (B) Flow diagram of systematic review. (C) Discrimination of the prediction models in development and external validation. Orange bars represent the C statistics of each model in the development phase, and blue bars represent the C statistics in the validation phase. Circles indicate point estimates, whereas horizontal lines denote 95% confidence intervals. (D) Relative risks of advanced colorectal neoplasia by quartile for each risk model. Circles indicate point estimates, whereas horizontal lines denote 95% confidence intervals. (E) Enrichment efficiency of risk-prediction models. FIT, fecal immunochemical test; BMI, body mass index; Q, quartile; ACN, advanced colorectal neoplasia; PPV, positive predictive value.



