12.

GRE 1,2-eliminase structure and schemes. (A) Reaction scheme for GD. (B) Reaction scheme for PD. (C) Reaction scheme for HypD. (D) Reaction scheme for HpyG. (E) Reaction scheme for HpzG. (F) Structure of GD (PDB ID: 1R9D) showing GOL (glycerol) bound. (G) Structure of PD (PDB ID: 5I2G) showing PDO (1,2-propanediol) bound. (H) Structure of HypD (PDB ID: 6VXE) showing t4L-HP (trans-4-hydroxy-L-proline) bound. (I) Structure of HpyG (PDB ID: 8ID1) showing c4L-NMHP (N-methyl cis-4-hydroxy-L-proline) bound. (J) Structure of HpzG (PDB ID: 8IOF) showing c4D-NMHP (N-methyl cis-4-hydroxy-D-proline) bound.