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. 2026 Jun 26;65(14):2227–2249. doi: 10.1021/acs.biochem.6c00318

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© 2026 The Authors. Published by American Chemical Society

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GRE isomerase structure and mechanism. (A) HplG reaction scheme. (B) YbiW reaction scheme. (C) PflD reaction scheme. (D) HplG (PDB ID: 7VUA) showing t4D-HP binding mode where C4 of t4D-HP is near Cys427 and Glu429 is hydrogen bonding to C4-OH. (E) YbiW (PDB ID: 8ID7) showing AG6P binding mode where C2 of AG6P is near Cys441 and Glu443 is hydrogen bonding to C2-OH. (F) PflD (PDB ID: 8ID0) showing AM6P binding mode where C2 of AM6P is near Cys431 and Glu433 is hydrogen bonding to C2-OH. (G) Reaction mechanism for YbiW.