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. 2026 Jun 26;65(14):2227–2249. doi: 10.1021/acs.biochem.6c00318

2. Area, Solvation Free Energy, and CSS of GRE Tetramer Interfaces.

PDB ID GRE area (Å2) solvation free energy upon tetramer formation from two dimers (kcal/mol) CSS (out of 1)
2YAJ hydroxyphenylacetate decarboxylase (HPAD) 865 –6.0 0
2F3O PFL2 1073 +10.2 0
8ID0 PflD 896 –6.3 0
a

Note that there is no solution state evidence for the formation of a tetrameric PflD. However, the tetrameric interface seen in other GREs exists within the crystal lattice of PflD and can therefore be analyzed with PDBePISA.