Table 1.

CXCL4-47-70 organizes DNA into liquid-crystalline supramolecular complexes at an inter-DNA spacing optimal for amplifying TLR9 activation

Condensing agent	Human DNA low degr	Human DNA med degr	Human DNA high degr
CXCL4	Disordered columnar q1 = 1.56 nm-1 d = 4.03 nm	Disordered columnar q1 = 1.55 nm-1 d = 4.05 nm	Disordered columnar q1 = 1.55 nm-1 d = 4.05 nm
CXCL4-47-70	Disordered columnar q1 = 1.64 nm-1 d = 3.83 nm	Disordered columnar q1 = 1.70 nm-1 d =3.70 nm	Disordered columnar q1 = 1.64 nm-1 d = 3.83 nm
CXCL4-L1 47-70	No signal	No signal	No signal

Values of the “q1” and “a” (distance between each DNA ligand) for CXCL4, CXCL4-47-70 and CXCL4-L1-47-70 in the presence of three different preparations of human DNA at low (DNA sonicated for 30 s), intermediate (DNA sonicated for 60 s) and high (DNA sonicated for 150 s) fragmentation (see Methods and ref. ³).

Data are from one representative experiment of two performed.