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. 2006 Jan 23;34(2):e14. doi: 10.1093/nar/gnj012

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© The Author 2006. Published by Oxford University Press. All rights reserved

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Structural selectivity revealed by melting studies of polynucleotide mixtures. Each panel shows the melting of a mixture of DNA [poly(dA)·poly (dT); peak 4], RNA [poly(rA)•poly (rU); peak 2], a DNA:RNA hybrid [poly (dA)•poly (rU); peak 1] and an RNA:DNA hybrid [poly(rA)•poly (dT); peak 3] as the solid black line. The concentration of each polynucleotide structure was 10 µM (bp); total polynucleotide concentration is 40 µM (bp). The dashed line in each panel shows the effect of addition of ligand. (A). Netropsin at 1.6 µM. (B) Ethidium at 1.5 µM. (C) A semi-synthetic derivative of the natural product β-lapachone (45) at 5 µM.