. Author manuscript; available in PMC: 2026 Aug 13.

Published in final edited form as: J Med Chem. 2026 Aug 13;69(15):18025–18050. doi: 10.1021/acs.jmedchem.6c00260

Table 3.

Broad-spectrum anti-filoviral activity of selected derivatives against pseudoviral Ebola (pEBOV), Sudan (pSUDV), Bundibugyo (pBDBV), and Tai Forest (pTAFV) viruses.

#	pEBOV EC₅₀ (μM)^a	pMARV EC₅₀ (μM)^a	pSUDV EC₅₀ (μM)^a	pBDBV EC₅₀ (μM)^a	pTAFV EC₅₀ (μM)^a
35	0.026 ± 0.005	0.44 ± 0.1	1.17 ± 0.13	> 10	1.10 ± 0.11
41	0.04 ± 0.002	0.42 ± 0.03	1.14 ± 0.13	> 10	0.67 ± 0.30
2	0.03 ± 0.004	2.53± 0.03	1.13 ± 0.34	> 10	3.88 ± 1.24

Dose–response curves were used to calculate EC₅₀ values using the four-parameter variable slope nonlinear regression analysis in GraphPad Prism 10.2.3. Data are presented as the mean EC₅₀ from three replicates ± standard deviation.