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. Author manuscript; available in PMC: 2026 Aug 13.
Published in final edited form as: J Med Chem. 2026 Aug 13;69(15):18025–18050. doi: 10.1021/acs.jmedchem.6c00260

Table 4.

Inhibitory activity of derivatives 35, 41, and 2 against pEBOV expressing wild-type (WT) and mutated GPs.a

pEBOV GP Mutants 35 41 2
EC50 (μM) EC50 (μM) EC50 (μM)
[Fold change] [Fold change] [Fold change]
WT 0.026±0.005 0.040±0.002 0.027±0.004
Y517S 0.68±0.25 1.12±0.04 15.56±4.64
[26] [28] [576]
Y517I 0.27±0.08 0.61±0.03 8.48±2.94
[10] [15] [314]
a

Dose–response curves were used to calculate EC50 values using the four-parameter variable slope nonlinear regression analysis in GraphPad Prism 10.2.3. Data are presented as the mean EC50 from three replicates ± standard deviation.