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. 2002 Feb;22(4):1049–1059. doi: 10.1128/MCB.22.4.1049-1059.2002

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Copyright © 2002, American Society for Microbiology

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FIG. 4. — Cell lines with defective S-phase checkpoint display prolonged G₂/M accumulation after IR. (A) Quantitation of G₂/M accumulation at various times after IR in normal (GM0536), AT (GM1526), and NBS (NBS7078A) lymphoblastoid cell lines. (B) Quantitation of G₂/M accumulation in normal (SVG), AT (GM9607), and NBS (NBS1-LBI) SV40-transformed fibroblast cell lines. (C) Quantitation of G₂/M accumulation at various times after IR in tumor cell lines with normal p53 function (SY5Y), lacking p53 (H1299), and lacking full-length Brca1 (HCC1937). All results are representative of at least three different experiments.