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. 2002 Feb;22(4):1049–1059. doi: 10.1128/MCB.22.4.1049-1059.2002

FIG. 7.

FIG. 7.

Radiation sensitivity and cell cycle checkpoint defects. (A) Expression of wild type Nbs1 (wtNbs1) or mutant Nbs1 (Serine 343 to alanine, S343A) rescues the hypersensitivity of NBS1-LBI cells in response to IR. (B) Expression of wild-type Brca1 (wtBrca1) or S1423A Brca1 rescues the radiation sensitivity of HCC1937 cells. Cells were exposed to 0 to 6 Gy of IR and incubated for 2 weeks prior to fixation, staining, and assessment of colony formation. The clonogenic survival assays were performed in triplicate. Standard errors are shown by error bars.