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Association of prolonged G2 accumulation with defective S-phase checkpointa
| Cell line and transfection | S-phase checkpoint | Early G2/M checkpoint | G2 accumulation | Radiation sensitivity |
|---|---|---|---|---|
| NBS1-LBI | ||||
| Vector | − | + | Prolonged | ↑ |
| Wild-type Nbs1 | + | + | + | + |
| S343A Nbs1 | − | + | Prolonged | + |
| HCC1937 | ||||
| Vector | − | − | Prolonged | ↑ |
| Wild-type Brca1 | + | + | + | + |
| S1423A Brca1 | + | − | + | + |
−, abnormal; +, normal; ↑, hypersensitive.
