Skip to main content
PMC home page
CMAJ : Canadian Medical Association Journal logoLink to CMAJ : Canadian Medical Association Journal
. 1985 Nov 15;133(10):997–1000.

Estrogen receptor status of breast cancer in Ontario

Gail E McKeown-Eyssen, Iris Rogers-Melamed, E Aileen Clarke
PMCID: PMC1346411  PMID: 4063915

Abstract

Data from a number of studies of breast cancer have suggested that after the ages associated with the menopause the rates of estrogen-receptor-positive tumours increase with age, whereas the rates of estrogen-receptor-negative tumours do not. Previous investigators studied cases in specific treatment centres, so there was a possibility that the findings were influenced by differences in patterns of case referral by age. A review of all the cases of breast cancer diagnosed in Ontario women in 1981 and assayed for estrogen receptors, however, confirmed the earlier findings. The results showed that the incidence of estrogen-receptor-positive and estrogen-receptor-negative tumours increased at about the same rate before age 45, but thereafter an increase in incidence was seen only for estrogen-receptor-positive tumours. These differences in patterns of incidence suggest the possibility that the two types of tumour may have different etiologic factors.

Full text

PDF
999

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abul-Hajj Y. J. Relationship between estrogen receptors, 17 beta-hydroxysteroid dehydrogenase and estrogen content in human breast cancer. Steroids. 1979 Aug;34(2):217–225. doi: 10.1016/0039-128x(79)90050-3. [DOI] [PubMed] [Google Scholar]
  2. Allegra J. C., Lippman M. E., Simon R., Thompson E. B., Barlock A., Green L., Huff K. K., Do H. M., Aitken S. C., Warren R. Association between steroid hormone receptor status and disease-free interval in breast cancer. Cancer Treat Rep. 1979 Aug;63(8):1271–1277. [PubMed] [Google Scholar]
  3. Cooke T., George D., Shields R., Maynard P., Griffiths K. Oestrogen receptors and prognosis in early breast cancer. Lancet. 1979 May 12;1(8124):995–997. doi: 10.1016/s0140-6736(79)92752-1. [DOI] [PubMed] [Google Scholar]
  4. Croton R., Cooke T., Holt S., George W. D., Nicolson R., Griffiths K. Oestrogen receptors and survival in early breast cancer. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1289–1291. doi: 10.1136/bmj.283.6302.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Drafta D., Prişcu A., Neacşu E., Gangură M., Schindler A. E., Stroe E., Anghel C., Panaitescu G. Estradiol and progesterone receptor levels in human breast cancer in relation to cytosol and plasma estrogen level. J Steroid Biochem. 1983 Apr;18(4):459–463. doi: 10.1016/0022-4731(83)90066-3. [DOI] [PubMed] [Google Scholar]
  6. Edery M., Goussard J., Dehennin L., Scholler R., Reiffsteck J., Drosdowsky M. A. Endogenous oestradiol-17beta concentration in breast tumours determined by mass fragmentography and by radioimmunoassay: relationship to receptor content. Eur J Cancer. 1981 Jan;17(1):115–120. doi: 10.1016/0014-2964(81)90220-6. [DOI] [PubMed] [Google Scholar]
  7. Elwood J. M., Godolphin W. Oestrogen receptors in breast tumours: associations with age, menopausal status and epidemiological and clinical features in 735 patients. Br J Cancer. 1980 Nov;42(5):635–644. doi: 10.1038/bjc.1980.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fishman J., Nisselbaum J. S., Menendez-Botet C. J., Schwartz M. K. Estrone and estradiol content in human breast tumors: relationship to estradiol receptors. J Steroid Biochem. 1977 Aug;8(8):893–896. doi: 10.1016/0022-4731(77)90100-5. [DOI] [PubMed] [Google Scholar]
  9. Hildreth N. G., Kelsey J. L., Eisenfeld A. J., LiVolsi V. A., Holford T. R., Fischer D. B. Differences in breast cancer risk factors according to the estrogen receptor level of the tumor. J Natl Cancer Inst. 1983 Jun;70(6):1027–1031. [PubMed] [Google Scholar]
  10. Ip C., Ip M. M. Serum estrogens and estrogen responsiveness in 7,12-dimethylbenz[a]anthracene-induced mammary tumors as influenced by dietary fat. J Natl Cancer Inst. 1981 Feb;66(2):291–295. [PubMed] [Google Scholar]
  11. Kuno K., Fukami A., Hori M., Kasumi F. Hormone receptors and obesity in Japanese women with breast cancer. Breast Cancer Res Treat. 1981;1(2):135–139. doi: 10.1007/BF01805867. [DOI] [PubMed] [Google Scholar]
  12. Lesser M. L., Rosen P. P., Senie R. T., Duthie K., Menendez-Botet C., Schwartz M. K. Estrogen and progesterone receptors in breast carcinoma: correlations with epidemiology and pathology. Cancer. 1981 Jul 15;48(2):299–309. doi: 10.1002/1097-0142(19810715)48:2<299::aid-cncr2820480215>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  13. McGuire W. L. Hormone receptors: their role in predicting prognosis and response to endocrine therapy. Semin Oncol. 1978 Dec;5(4):428–433. [PubMed] [Google Scholar]
  14. Nagai R., Kataoka M., Kobayashi S., Ishihara K., Tobioka N., Nakashima K., Naruse M., Saito K., Sakuma S. Estrogen and progesterone receptors in human breast cancer with concomitant assay of plasma 17beta-estradiol, progesterone, and prolactin levels. Cancer Res. 1979 May;39(5):1834–1840. [PubMed] [Google Scholar]
  15. Nomura Y., Kanda K., Shigematsu T., Narita N., Matsumoto K., Sugano H. Relation between estrogen receptors and body weight in Japanese pre- and post-menopausal breast cancer patients. Gan. 1981 Jun;72(3):468–469. [PubMed] [Google Scholar]
  16. Nomura Y., Kobayashi S., Takatani O., Sugano H., Matsumoto K., McGuire W. L. Estrogen receptor and endocrine responsiveness in Japanese versus American breast cancer patients. Cancer Res. 1977 Jan;37(1):106–110. [PubMed] [Google Scholar]
  17. Nomura Y., Tashiro H., Hamada Y., Shigematsu T. Relationship between estrogen receptors and risk factors of breast cancer in Japanese pre- and postmenopausal patients. Breast Cancer Res Treat. 1984;4(1):37–43. doi: 10.1007/BF01806986. [DOI] [PubMed] [Google Scholar]
  18. Papatestas A. E., Panveliwalla D., Pertsemlidis D., Mulvihill M., Aufses A. H., Jr Association between estrogen receptors and weight in women with breast cancer. J Surg Oncol. 1980;13(2):177–180. doi: 10.1002/jso.2930130213. [DOI] [PubMed] [Google Scholar]
  19. Rich M. A., Furmanski P., Brooks S. C. Prognostic value of estrogen receptor determinations in patients with breast cancer. Cancer Res. 1978 Nov;38(11 Pt 2):4296–4298. [PubMed] [Google Scholar]
  20. Ryan E. D., Clark A. F., Mobbs B. G., Ooi T. C., Sutherland D. J., Tustanoff E. R. Inter-laboratory quality control of estrogen and progesterone receptor assays in breast cancer tissue using lyophilised cytosols. Clin Biochem. 1985 Feb;18(1):20–26. doi: 10.1016/s0009-9120(85)80018-7. [DOI] [PubMed] [Google Scholar]
  21. Saez S., Martin P. M., Chouvet C. D. Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma estrogen and progesterone levels. Cancer Res. 1978 Oct;38(10):3468–3473. [PubMed] [Google Scholar]
  22. Sakai F., Saez S. Existence of receptors bound to endogenous estradiol in breast cancers of premenopausal and postmenopausal women. Steroids. 1976 Jan;27(1):99–110. doi: 10.1016/0039-128x(76)90071-4. [DOI] [PubMed] [Google Scholar]
  23. Theve N. O., Carlström K., Gustafsson J. A., Gustafsson S., Nordenskjöld B., Sköldefors H., Wrange O. Oestrogen receptors and peripheral serum levels of oestradiol-17beta in patients with mammary carcinoma. Eur J Cancer. 1978 Dec;14(12):1337–1340. doi: 10.1016/0014-2964(78)90115-9. [DOI] [PubMed] [Google Scholar]
  24. Thorsen T., Tangen M., Støa K. F. Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol. Eur J Cancer Clin Oncol. 1982 Apr;18(4):333–337. doi: 10.1016/0277-5379(82)90002-5. [DOI] [PubMed] [Google Scholar]
  25. Wallace R. B., Sherman B. M., Bean J. A. A relationship between artifical menopause, previous estrogen consumption, and estrogen receptor content of breast neoplasms: preliminary communication. Oncology. 1980;37(2):111–113. doi: 10.1159/000225416. [DOI] [PubMed] [Google Scholar]

Articles from CMAJ: Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES