Abstract
Although rare, neutropenia associated with long-term vancomycin therapy may occur. A 67-year-old woman with cellulitis and sepsis caused by Staphylococcus aureus was treated initially with cefazolin. Despite in-vitro susceptibility of the organism to this drug, the patient remained febrile, and therapy was changed to vancomycin. On day 17 of therapy with this medication neutropenia was noted; it progressed over the next 3 days, and therapy with the drug was stopped. A rise in the neutrophil count occurred within 5 days of discontinuation. Periodic monitoring of the leukocyte count during longterm vancomycin therapy is recommended.
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Selected References
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- Borland C. D., Farrar W. E. Reversible neutropenia from vancomycin. JAMA. 1979 Nov 30;242(22):2392–2393. [PubMed] [Google Scholar]
- Farber B. F., Moellering R. C., Jr Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981. Antimicrob Agents Chemother. 1983 Jan;23(1):138–141. doi: 10.1128/aac.23.1.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gopal V., Bisno A. L., Silverblatt F. J. Failure of vancomycin treatment in Staphylococcus aureus endocarditis. In vivo and in vitro observations. JAMA. 1976 Oct 4;236(14):1604–1606. [PubMed] [Google Scholar]
- Hook E. W., 3rd, Johnson W. D., Jr Vancomycin therapy of bacterial endocarditis. Am J Med. 1978 Sep;65(3):411–415. doi: 10.1016/0002-9343(78)90766-0. [DOI] [PubMed] [Google Scholar]
- Kauffman C. A., Severance P. J., Silva J., Jr, Huard T. K. Neutropenia associated with vancomycin therapy. South Med J. 1982 Sep;75(9):1131–1133. doi: 10.1097/00007611-198209000-00029. [DOI] [PubMed] [Google Scholar]
- Kesarwala H. H., Rahill W. J., Amaram N. Vancomycin induced neutropenia. Lancet. 1981 Jun 27;1(8235):1423–1423. doi: 10.1016/s0140-6736(81)92598-8. [DOI] [PubMed] [Google Scholar]
- Strikas R., Studlo J., Venezio F. R., O'Keefe J. P. Vancomycin-induced neutropenia. J Infect Dis. 1982 Oct;146(4):575–575. doi: 10.1093/infdis/146.4.575. [DOI] [PubMed] [Google Scholar]
- Weitzman S. A., Stossel T. P. Drug-induced immunological neutropenia. Lancet. 1978 May 20;1(8073):1068–1072. doi: 10.1016/s0140-6736(78)90915-7. [DOI] [PubMed] [Google Scholar]
- West B. C. Vancomycin-induced neutropenia. South Med J. 1981 Oct;74(10):1255–1256. doi: 10.1097/00007611-198110000-00028. [DOI] [PubMed] [Google Scholar]