TABLE 5.
SxxK acyltransferases of M. tuberculosis, M. leprae, C. diphtheriae, and S.coelicolora
Type | Class | PBP and Penr protein fusions
|
Similarity index vs M. tuberculosis
|
Gene environ- ment | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M. tuberculosis
|
M. leprae | C. diph- theriae | S. coelicolor |
P (10−n)
|
I (%)
|
|||||||||
Protein | Mr | kDa | M. leprae | C. diphtheriae | S. coelicolor | M. leprae | C. diphtheriae | S. coelicolor | ||||||
PBP | A | 0050 (Mtu1s) | 71,151 | 94-82 | 2688 (Mle1s) | 378 | H24.23 | ∞ | 173 | 74 | 83 | 51 | 37 | |
E6.34 | 71 | 35 | ||||||||||||
K7.12 | 41 | 30 | ||||||||||||
B3 | 2163 (Mtu3) | 72,506 | 94-82 | 0908 (Mle3) | 101 | 4A10.23 (Sco3) | ∞ | 163 | 82 | 80 | 51 | 33 | dcw | |
B2 | C88.19 (Sco2) | mre, sfr | ||||||||||||
B-like I | 0016 | 51,776 | 52 | 0018 | 16 | H69.17 | ∞ | 107 | 80 | 85 | 45 | 36 | sfr | |
6G9.32 | 79 | 39 | sfr | |||||||||||
2st10A7 | 78 | 35 | ||||||||||||
Penr | A | 3682 (Mtu1r) | 84,636 | 2308 (Mle1r) | 338 | H17.14 | ∞ | ∞ | 51 | 86 | 48 | 36 | ||
B-like II | 2864 | 63,015 | 1577 | 230 | ∞ | 118 | 80 | 41 | ||||||
B-like III | H63.18 | 38* | 27* | |||||||||||
E87.08 | 27* | 34* | ||||||||||||
E87.07 | 33* | 33* |
Similarity indexes P and I apply to full-size protein fusions except for S. coelicolor protein fusions H63.18, E87.08, and E87.07 (*), where similarity with protein fusion Mtu2864 is restricted to the acyltransferase modules.