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. 2026 Jul 27;15(15):1345. doi: 10.3390/cells15151345
17β-HSD7 17β-hydroxysteroid dehydrogenase type 7
AI aromatase inhibitor
AR androgen receptor
BC breast cancer
CCAC Canadian Council on Animal Care
DHT dihydrotestosterone
DMSO dimethyl sulfoxide
DHEA dehydroepiandrosterone
DMEM Dulbecco’s modified Eagle medium
E1 estrone
E2 estradiol
EC50 half maximal effective concentration
ER+ estrogen receptor positive
FBS fetal bovine serum
GC-MS gas chromatography tandem mass spectrometry
HEK human embryonic kidney
hERG ether-a-go-go-related gene
HF hormone-free
IC50 half maximal inhibitory concentration
MC methylcellulose aqueous
MEM minimum essential media
OVX ovariectomized
PI propidium iodide
pM picomolar
PTX paclitaxel
PVDF polyvinylidene difluoride
RPMI Roswell Park Memorial Institute
SERM selective estrogen-receptor modulator
T testosterone
TLC thin-layer chromatography