TABLE 1.
Cardiac inflammation and tissue parasitism
| Mouse strain | Time (days) p.i. | Avg inflammation scorea ± SD
|
Tissue parasitism (mean no. of infected cells/ 100 mm2 ± SE) | n | |
|---|---|---|---|---|---|
| Atrium | Ventricle | ||||
| CCR5+/+ | 0 | 0.60 ± 0.55 | 0.67 ± 0.82 | 0.00 | 6 |
| 15 | 2.11 ± 0.33 | 2.00 ± 0.00 | 0.18 ± 0.18 | 10 | |
| 30 | 4.00 ± 0.00 | 4.00 ± 0.00 | 34.20 ± 9.92 | 6 | |
| 60 | 3.75 ± 0.50 | 3.50 ± 0.58 | 1.40 ± .90 | 4 | |
| 120 | 2.25 ± 0.50 | 2.00 ± 0.00 | 0.00 | 4 | |
| 200 | 3.00 ± 0.00 | 3.67 ± 0.58 | 0.00 | 3 | |
| CCR5−/− | 0 | 0.40 ± 0.55 | 0.80 ± 0.45 | 0.00 | 5 |
| 15 | 0.40 ± 0.55b | 0.57 ± 0.53b | 0.70 ± 0.70 | 7 | |
| 30 | 3.67 ± 0.65 | 3.67 ± 0.65 | 163.64 ± 25.97b | 12 | |
| 60 | 3.00 ± 1.00 | 3.50 ± 0.58 | 2.34 ± 1.52 | 4 | |
| 120 | 3.50 ± 1.22 | 3.17 ± 0.75 | 0.29 ± 0.29 | 6 | |
| 200 | 2.25 ± 0.50 | 2.50 ± 0.58 | 0.00 | 4 | |
Using the numerical scoring system of Sun and Tarleton (43).
Significant difference between CCR5−/− and CCR5+/+ mice at the same time p.i., as determined by the Mann-Whitney test (P ≤ 0.01).