TABLE 2.
Cardiac inflammation and tissue parasitism in RAG1−/− micea
| Spleenocytes transferred | Time (days) p.i. | Avg inflammation scorea ± SD
|
Tissue parasitism (avg no. of infected cells/100 mm2 ± SE) | No. of survivors/total no. | |
|---|---|---|---|---|---|
| Atrium | Ventricle | ||||
| CCR5+/+ | 30 | 3.60 ± 0.55*§ | 2.67 ± 0.52*§ | 733.75 ± 327.38*§ | 6/9 |
| CCR5−/− | 30 | 2.43 ± 0.79 | 2.14 ± 0.38 | 1,410.89 ± 485.54§§ | 7/9 |
| HBSS | 30 | 2.29 ± 0.49 | 2.00 ± 0.00 | 2,917.97 ± 664.51 | 8/8 |
a
The average inflammation score is based on the numerical scoring system of Sun and Tarleton (43). Symbols: *, significantly different from mice receiving CCR5−/− spleenocytes (Mann-Whitney test, P ≤ 0.1); §, significantly different from mice receiving HBSS (Mann-Whitney test, P ≤ 0.05); §§, significantly different from mice receiving HBSS (Mann-Whitney test, P ≤ 0.1).