TABLE 2.
Cardiac inflammation and tissue parasitism following chemokine neutralization
| Antibody treatment | Days p.i. | Avg inflammation score ± SDa
|
Tissue parasitism (no. of infected cells/100 mm2) ± SE | |
|---|---|---|---|---|
| Atrium | Ventricle | |||
| IgG1 + IgG2b | 15 | 2.00 ± 1.00 | 1.67 ± 0.58 | 1.59 ± 1.43 |
| 30 | 4.00 ± 0.00 | 3.67 ± 0.58 | 15.70 ± 6.30 | |
| 60 | 4.00 ± 0.00 | 4.00 ± 0.00 | 0.86 ± 1.50 | |
| Anti-CXCL9 + anti-CXCL10 | 15 | 2.00 ± 0.00 | 2.00 ± 0.00 | 0.00 ± 0.00 |
| 30 | 4.00 ± 0.00 | 4.00 ± 0.00 | 33.59 ± 13.75b | |
| 60 | 4.00 ± 0.00 | 3.67 ± 0.58 | 3.57 ± 5.00 | |
a
Using the numerical scoring system of Sun and Tarleton (32).
b
Significantly different from isotype control (Student's t test, P ≤ 0.05). Data represent three mice per group per time point.