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. 2026 Jul 28;15(15):5901. doi: 10.3390/jcm15155901
VML volumetric muscle loss
ECM extracellular matrix
FDA Food and Drug Administration
μm micrometer
MRFs myogenic regulatory factors
bHLH Basic Helix-Loop-Helix
MyoD myogenic differentiation 1
DMD Duchenne Muscular Dystrophy
FFMT free functional muscle transfer
GelMA gelatin methacrylate
RGD arginylglycylaspartic Acid
CNTs carbon nanotubes
PPY polypyrrole
PANI polyaniline
ES electrospinning
iPSCs Induced Pluripotent Stem Cells
hESCs human embryonic stem cells
NMJ neuromuscular junction
MSCs mesenchymal stem cells
ADSCs adipose-derived stem cells
MPC-Exo Myogenic Progenitor Cell-Derived Exosomes
qRT-PCR Quantitative Reverse Transcription Polymerase Chain Reaction
MYOD Myogenic Differentiation Marker
MYOG myogenin
PAX7 Paired Box 7
CCK-8 Cell Counting Kit-8
SD Standard Deviation
TNF-α tumor necrosis factor-alpha
NF-κB Nuclear Factor Kappa B
PRP platelet-rich plasma
α-SMA Alpha-Smooth Muscle Actin
VEGF vascular endothelial growth factor
PI3K/Akt Phosphoinositide 3-Kinase/Protein Kinase B
sEVs small extracellular vesicles
ATP Adenosine Triphosphate
PGC-1α Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha
IL Interleukin
Hz hertz
INTEM innervated tissue-engineered muscle
NT-3 neurotrophin-3
BDNF Brain-Derived Neurotrophic Factor
AChRs Acetylcholine Receptors
IFN-γ Interferon-Gamma
IGF-1 insulin-like growth factor-1
TGF-β1 transforming growth factor-beta 1
HCT/P Human Cells, Tissues, and Cellular and Tissue-Based Products
PMA Premarket Approval
CDRH Center for Devices and Radiological Health
CBER Center for Biologics Evaluation and Research
CDER Center for Drug Evaluation and Research
RMAT Regenerative Medicine Advanced Therapy
GMP good manufacturing practice