TABLE 1.
Antimicrobial and pharmacokinetic properties of antibiotic-loaded hip spacers after 14 days in vitro
| Spacer | Implantation period (wk) | Duration of bacterial growth inhibition (days) | Release of antibiotic in μg (% release) after 14 days
|
|
|---|---|---|---|---|
| Gentamicin | Vancomycin | |||
| 1 | 12 | 14 | 18,563.3 (1.85) | 47,467.4 (1.19) |
| 2 | 8 | 14 | 23,857.9 (2.38) | 39,652.0 (0.99) |
| 3 | 12 | 15 | 24,628.2 (2.46) | 75,497.0 (1.89) |
| 4 | 14 | 15 | 27,641.4 (2.76) | 28,363.6 (0.71) |
| 5 | 3 | 30 | 25,467.9 (2.54) | 75,039.8 (1.88) |
| 6 | 7 | 15 | 21,279.6 (2.12) | 52,053.6 (1.30) |
| 7 | 14 | 16 | 28,474.0 (2.84) | 64,209.1 (1.60) |
| 8 | 13 | 16 | 16,162.1 (1.61) | 32,211.5 (0.81) |
| 9 | 8 | 14 | 15,288.1 (1.52) | 24,244.3 (0.61) |
| 10 | 4 | 18 | 15,336.4 (1.53) | 54,726.2 (1.09) |