TABLE 3.

Pharmacokinetic parameters of prodrug cleavage product BAL8728 estimated after single intravenous infusions of BAL8557^a

Parameter	Dose
	50 mg	100 mg	200 mg
AUC0-∞ (μg·h/ml)	0.118b (±0.008)	0.250 (±0.063)	0.681 (±0.113)
AUClast (μg·h/ml)	0.094 (±0.010)	0.234 (±0.065)	0.658 (±0.114)
Cmax (μg/ml)	0.081 (±0.008)	0.209 (±0.068)	0.615 (±0.140)
Tmax (h)	1.0 (1.0-1.0)	0.88 (0.75-1.0)	1.0 (0.75-1.0)
t1/2 (h)	1.01b (±0.43)	0.69 (±0.14)	0.83 (±0.15)

^aInfusion doses were equivalent to 50, 100, and 200 mg of BAL4815. Results shown are from six subjects except where indicated. Values are presented as arithmetic means plus or minus SD; median and range are listed for T_max.

^bn = 4 (t_1/2 was not assessable for two subjects).