A, Mean plasma profiles of BAL4815 after oral administration of BAL8557 (cohort 1, loading dose of 100-mg equivalents of BAL4815 followed by once-daily maintenance doses of 50 mg; cohort 2, loading dose of 200-mg equivalents of BAL4815 followed by once-daily maintenance doses of 100 mg). B, Mean plasma profiles of BAL4815 after intravenous infusion of BAL8557 (cohort 3, loading dose of 100-mg equivalents of BAL4815 followed by once-daily maintenance doses of 50 mg; cohort 4, loading dose of 200-mg equivalents of BAL4815 followed by once-daily maintenance doses of 100 mg).