Table 2.

CINeMA confidence assessment for primary exercise-versus-control comparisons.

Outcome	Comparison	Number of studies	Within-study bias	Reporting bias	Indirectness	Imprecision	Heterogeneity	Incoherence	Confidence rating
O1 Addictive craving	AE vs CON	15	Some concerns	No concerns	No concerns	No concerns	Some concerns	No concerns	Low
	YME vs CON	2	Some concerns	Some concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	MBE vs CON	6	Some concerns	No concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	RSE vs CON	7	Some concerns	No concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	ME vs CON	8	Some concerns	No concerns	No concerns	No concerns	Some concerns	No concerns	Low
O2 Negative affect	AE vs CON	8	Some concerns	No concerns	No concerns	No concerns	Some concerns	No concerns	Low
	YME vs CON	5	Some concerns	No concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	MBE vs CON	8	Some concerns	No concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	RSE vs CON	5	Some concerns	No concerns	No concerns	Major concerns	Some concerns	No concerns	Very low
	ME vs CON	5	Some concerns	No concerns	No concerns	Some concerns	Some concerns	No concerns	Very low
O3 Cognitive function	AE vs CON	15	Some concerns	No concerns	Some concerns	Major concerns	Major concerns	No concerns	Very low
	YME vs CON	4	Some concerns	No concerns	Some concerns	Major concerns	Major concerns	No concerns	Very low
	MBE vs CON	3	Some concerns	Some concerns	Some concerns	Major concerns	Major concerns	No concerns	Very low
	RSE vs CON	8	Some concerns	No concerns	Some concerns	Major concerns	Major concerns	No concerns	Very low
	ME vs CON	5	Some concerns	No concerns	Some concerns	Major concerns	Major concerns	No concerns	Very low

Green shading indicates “no concerns,” yellow shading indicates “some concerns,” and red shading indicates “major concerns” in the CINeMA domain-level assessments. The unshaded final column presents the overall confidence rating.