TABLE 2.
Pharmacokinetics parameters of linezolida
| Subject and pharmacokinetic parameter | Linezolid (mean ± SD) | Linezolid + Maalox (mean ± SD) | Geometric mean ratio | 90% CI (P value) |
|---|---|---|---|---|
| Females (n = 9) | ||||
| Cmax (mg/liter) | 16.2 ± 2.4 | 15.5 ± 2.2 | 0.98 | 0.96-1.01 |
| NS | ||||
| AUC0-∞ (mg · h/liter) | 126.7 ± 28.8 | 133.0 ± 36.3 | 1.01 | 0.98-1.03 |
| NS | ||||
| Tmax (h) | 1.22 ± 0.57 | 1.02 ± 0.42 | NS | |
| t1/2 (h) | 4.65 ± 1.16 | 4.95 ± 1.64 | NS | |
| V/F (liters) | 31.8 ± 3.26 | 31.9 ± 3.67 | NS | |
| CL/F (liters/h) | 4.99 ± 1.30 | 4.89 ± 1.66 | NS | |
| Males (n = 9) | ||||
| Cmax (mg/liter) | 13.4 ± 1.9 | 13.3 ± 2.7 | 0.99 | 0.93-1.06 |
| NS | ||||
| AUC0-∞ (mg · h/liter) | 93.3 ± 22.9 | 95.1 ± 23.5 | 1.00 | 0.98-1.03 |
| NS | ||||
| Tmax (h) | 1.00 ± 0.50 | 1.2 ± 0.87 | NS | |
| t1/2 (h) | 4.52 ± 1.54 | 4.66 ± 1.44 | NS | |
| V/F (liters) | 41.5 ± 6.0 | 42.1 ± 6.3 | NS | |
| CL/F (liters/h) | 6.79 ± 1.71 | 6.65 ± 1.67 | NS | |
| All subjects (n = 18) | ||||
| Cmax (mg/liter) | 14.8 (2.5) | 14.4 ± 2.6 | 0.99 | 0.96-1.2 |
| NS | ||||
| AUC0-∞ (mg · h/liter) | 110.0 (30.5) | 114.1 ± 35.5 | 1.01 | 0.99-1.02 |
| NS | ||||
| Tmax (h) | 1.11 ± 0.53 | 1.09 ± 0.67 | NS | |
| t1/2 (h) | 4.58 ± 1.32 | 4.80 ± 1.50 | NS | |
| V/F (liters) | 36.7 ± 6.9 | 37.0 ± 7.3 | NS | |
| CL/F (liters/h) | 5.89 ± 1.74 | 5.77 ± 1.85 | NS |
a
Significant differences due to sex for V/F (P = 0.002); significant differences due to body weight for AUC (P = 0.012) and CL/F (P = 0.02); when normalized by body weight, a significant effect of sex on AUC (P < 0.001) and Cmax (P = 0.001) was observed. Abbreviations: NS, not statistically significant different; CI, confidence interval; CV, coefficient of variation.