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. 2006 Jan;50(1):88–95. doi: 10.1128/AAC.50.1.88-95.2006

FIG. 2.

FIG. 2.

Comparison of mouse (spleen, top left; liver, top right) and Leishmania (spleen, bottom left; liver, bottom right) γ-GCS levels in the livers and spleens of L. donovani-infected mice. Spleen and liver samples were obtained from mice infected with the SSG-S or SSG-R strain of L. donovani on day 14 postinfection. Mice were treated with PBS alone (controls), free SSG (SSG final dose, 70 mg Sbv/kg), BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with water, or BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with SSG solution (SSG final dose, 70 mg Sbv/kg; BSO-NIV/SSG treatment). The mean relative expression of the mouse γ-GCS plus SE and the Leishmania γ-GCS plus SE was determined using the mean value for the SSG-S strain as the normalizer. The data are representative of two separate experiments which show the same significant differences between treatments indicated. *, P < 0.05 compared to the relevant control.