FIG. 3.
Effect of different treatments on the spleen, liver, and bone marrow parasite burdens of mice infected with the SSG-S (left) or SSG-R (right) strains of L. donovani on day 14 postinfection. Mice infected with the SSG-S or SSG-R strain of L. donovani were treated with PBS alone (control), free SSG (SSG final dose, 70 mg Sbv/kg), GSH-NIV (final GSH dose, 89 mg/kg) mixed 1:1 (vol/vol) with water, or GSH-NIV (final GSH dose 89 mg/kg) mixed 1:1 (vol/vol) with SSG solution (SSG final dose, 70 mg Sbv/kg; GSH-NIV/SSG treatment). ***, P < 0.001 compared to the relevant control. The data are representative of three separate experiments, which show the same significant differences between the treatments indicated.