TABLE 1.

Effect of different treatments on the spleen, liver, and bone marrow parasite burdens of mice infected with the SSG-S or SSG-R strain of L. donovani on day 14 postinfection^a

Strain and treatment	Mean parasite suppression (%) ± SE in:
	Spleen	Liver	Bone marrow
SSG-S
SSG	0 ± 0	42 ± 11**	0 ± 0
BSO-NIV	0 ± 0	44 ± 3**	0 ± 0
BSO-NIV/SSG	98 ± 1***	99 ± 1***	97 ± 4**
SSG-R
SSG	27 ± 14	4 ± 4	25 ± 14
BSO-NIV	36 ± 3	23 ± 14	37 ± 16
BSO-NIV/SSG	47 ± 18	98 ± 1***	50 ± 14

^aMice infected with the SSG-S or SSG-R strain of L. donovani were treated on day 7 postinfection with PBS alone (control), free SSG (equivalent to a final dose of 70 mg Sb^v/kg), BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with water, or BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with SSG solution (SSG final dose of 70 mg Sb^v/kg; BSO-NIV / SSG treatment). **, P < 0.001; ***, P < 0.0001, compared to the relevant control.