TABLE 1.
Strain and treatment | Mean parasite suppression (%) ± SE in:
|
||
---|---|---|---|
Spleen | Liver | Bone marrow | |
SSG-S | |||
SSG | 0 ± 0 | 42 ± 11** | 0 ± 0 |
BSO-NIV | 0 ± 0 | 44 ± 3** | 0 ± 0 |
BSO-NIV/SSG | 98 ± 1*** | 99 ± 1*** | 97 ± 4** |
SSG-R | |||
SSG | 27 ± 14 | 4 ± 4 | 25 ± 14 |
BSO-NIV | 36 ± 3 | 23 ± 14 | 37 ± 16 |
BSO-NIV/SSG | 47 ± 18 | 98 ± 1*** | 50 ± 14 |
Mice infected with the SSG-S or SSG-R strain of L. donovani were treated on day 7 postinfection with PBS alone (control), free SSG (equivalent to a final dose of 70 mg Sbv/kg), BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with water, or BSO-NIV (final BSO dose, 34.7 mg/kg) mixed 1:1 (vol/vol) with SSG solution (SSG final dose of 70 mg Sbv/kg; BSO-NIV / SSG treatment). **, P < 0.001; ***, P < 0.0001, compared to the relevant control.