FIG. 3.

Putative l-CA-binding pocket on HIV IN. (A) l-CA modeled into the catalytic core domain of IN. The region in light gray is the area on IN that comprises the putative inhibitor-binding pocket. The indicated amino acids are those proposed to interact with l-CA. This model was provided by T. Charvat and A. R. Chamberlin (published with permission). (B) Schematic of the specific amino acid-inhibitor contacts for l-CA based on studies by Sotriffer et al. (41). Hatched lines, hydrogen bonding and potential salt bridges.