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. 2006 Jan;50(1):318–323. doi: 10.1128/AAC.50.1.318-323.2006

FIG. 1.

FIG. 1.

Evolution of the QS blocker compound 3. Compound 1, which was originally identified as a structural homologue of 3-oxo-C12-HSL, provided the basis for the design of QS antagonists that specifically block the Burkholderia cep system. The activity of the compound was successively improved by iterative rounds of rational molecule design and activity testing. (A) Structures of compounds 1, 2, and 3. (B) Alignment of compound 1 with 3-oxo-C12-HSL and of compounds 2 and 3 with C8-HSL. (C) Antagonistic activities of the compounds in the P. putida F117(pAS-C8)-based bioassay.