TABLE 1.

Mutations associated with reduced susceptibility to NNRTIs^a

Mutation (nb)	Drug
	NVP				DLV				EFV
	% FC < 5c	% FC > 5d	ORe	P valuef	% FC < 5	% FC > 5	OR	P value	% FC < 5	% FC > 5	OR	P value
I31L (50)	0.2	2.9	16.9	<0.0001	0.2	1.8	10.8	<0.0001	0.2	3.8	20.4	<0.0001
K64N (97)	0.4	1.9	5.1	0.0082	0.4	0.6	1.5	0.6854	0.4	1.3	3.2	0.3369
L74I (285)	1.1	5.2	4.6	<0.0001	1.2	2.3	1.9	0.1299	1.1	6.3	5.5	0.0003
V75I (171)	0.7	1.9	2.8	0.0657	0.7	1.0	1.4	0.6325	0.7	3.8	5.5	0.0084
K101P (40)	0.02	11.7	694	<0.0001	0.03	6.8	227	<0.0001	0.02	22.5	1349	<0.0001
K101Q (344)	1.3	10.0	7.6	<0.0001	1.4	4.9	3.6	<0.0001	1.4	5.6	4.0	0.0054
K101H (43)	0.1	3.6	26.5	<0.0001	0.1	3.5	31.4	<0.0001	0.2	1.9	11.2	0.0194
K103R (562)	2.1	17.2	8.0	<0.0001	2.1	11.9	5.6	<0.0001	2.1	32.5	15.3	<0.0001
V108I (324)	1.2	10.7	8.7	<0.0001	1.3	4.3	3.3	<0.0001	1.3	7.5	5.8	<0.0001
D123K (146)	0.6	1.9	3.3	0.0388	0.6	1.8	3.2	0.0128	0.6	3.1	5.3	0.0189
E138A (602)	2.5	5.2	2.1	0.0221	2.2	16.4	7.5	<0.0001	2.5	2.5	1.0	1.1412
E138K (57)	0.2	0.0	0.0	1.0601	0.2	1.4	6.9	0.0009	0.2	0.0	0.0	1.1345
E138G (79)	0.3	1.6	5.2	0.0152	0.3	1.6	5.4	0.0013	0.3	1.9	5.9	0.0645
T139R (55)	0.2	1.3	6.1	0.0217	0.2	1.6	8.2	0.0001	0.2	0.6	2.8	0.5773
T165L (61)	0.2	2.3	10.0	0.0001	0.2	1.2	5.3	0.0068	0.2	1.9	7.8	0.0396
V179D (350)	1.2	19.7	16.3	<0.0001	1.0	24.6	25.5	<0.0001	1.2	45.6	39.5	<0.0001
V179E (117)	0.4	3.2	7.2	<0.0001	0.3	9.8	33.9	<0.0001	0.4	15.6	40.7	<0.0001
D218E (552)	2.2	8.4	3.8	<0.0001	2.2	4.7	2.1	0.0059	2.2	11.3	5.1	<0.0001
K219H (32)	0.1	0.6	5.1	0.1546	0.1	1.2	11.1	0.0003	0.1	0.6	4.8	0.4376
K219N (209)	0.8	3.2	3.9	0.0025	0.8	1.6	1.9	0.1742	0.8	4.4	5.2	0.0051
H221Y (172)	0.7	4.5	6.8	<0.0001	0.7	2.7	4.0	0.0004	0.7	5.6	8.3	<0.0001
K238T (59)	0.2	4.9	26.3	<0.0001	0.2	2.0	9.8	<0.0001	0.2	2.5	10.9	0.0062
E297P (80)	0.3	2.3	7.4	0.0006	0.3	1.2	3.9	0.0223	0.3	1.3	3.8	0.2659
E300A (37)	0.1	1.9	14.9	<0.0001	0.2	0.0	0.0	1.0052	0.2	0.0	0.0	1.0104

^aMutations with a P value of <0.05 and odds ratio of >5 for at least one NNRTI are listed.

^bn, no. of samples.

^cPercentage of NNRTI-sensitive samples (FC < 5.0) with mutation.

^dPercentage of NNRTI-resistant samples (FC > 5.0) with mutation.

^eOdds ratio (ratio of percent resistant with mutation to percent sensitive with mutation).

^fFisher's exact test with Benjamini correction; mixtures counted as mutant; bold if P value is <0.05.