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Replication of the G1862C, T1863A, and C1869A single mutants or double mutants with G1899A. Also included are N4, the parental construct, and HBV5.4, a clone defective in genome replication. Shown is intracellular HBV DNA associated with core particles. L, linear HBV DNA; SS, single-stranded HBV DNA; +, present; −, absent. Levels of HBsAg in culture supernatant are provided.
