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. 2026 Jul 24;31(15):2592. doi: 10.3390/molecules31152592
DABCO 1,4-Diazabicyclo[2.2.2]octane
DBU 1,8-Diazabicyclo[5.4.0]undec-7-ene
DCM Dichloromethane
DEA N,N-Diethylaniline
DIAD Diisopropylazadicarboxylate
DMAP 4-Dimethylaminopyridine
DMEDA N,N′-Dimethylethylenediamine
DMF N,N-Dimethylformamide
DMSO Dimethylsulfoxide
DOR δ-opioid receptor
EGFR Epidermal Growth Factor Receptor
GABA Gamma-aminobutyric acid
H4Ac Acetylated histone H4
HSF1 Heat-shock transcription factor 1
IC50 Half-maximal inhibitory concentration
IKK IκB kinase (inhibitor of nuclear factor kappa-B kinase)
iNOS Inducible nitric oxide synthase
KOR κ-opioid receptor
MAO Monoamine oxidase
MCR Multicomponent reaction
MOR μ-opioid receptor
MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
NAM Negative allosteric modulator
NaHMDS Sodium bis(trimethylsilyl)amide
NMR Nuclear magnetic resonance
PAM Positive allosteric modulator
PDE2 Phosphodiesterase-2
PI3K Phosphoinositide 3-kinase
PRMT5 Protein arginine methyltransferase 5
PPhMe2 Dimethylphenylphosphine
PROTAC PROteolysis TArgeting Chimera
SAR Structure–activity relationship
SEM Standard error of the mean
SI Selectivity index
STING Stimulator of interferon genes
Syk Spleen tyrosine kinase
TBAF Tetrabutylammonium fluoride
TEA Triethylamine
TFA Trifluoroacetic acid
THF Tetrahydrofuran
TLR Toll-like receptor
TMEDA Tetramethylethylenediamine
TopoII Topoisomerase II
TPP Triphenylphosphine
VEGFR2 Vascular endothelial growth factor receptor 2