TABLE 2.

Convergent PNG changes in gp120 at 32 wpi^a

Sample	(N)b	Prevalence (%) of indicated PNG
		V1V2						C2		C3	V4		V5
		136	139	139C	141	186	188	234	276	362	386	397	460	462/3
Inoculumc	8	100	100	88	0	100	0	100	0	100	0	38	100	0
K97107	8	100	100	100	25	75	25	75	0	100	0	0	100	0
K98099	9	100	100	100	0	100	0	100	0	100	0	0	100	0
L97191	9	100	100	33	0	100	0	100	0	100	0	0	100	0
J97168	9	100	100	56	0	89	0	100	0	100	0	33	100	0
A98069	9	100	100	89	56	33	0	100	0	100	67	22	100	0
T98098	9	100	100	78	55	44	56	100	33	78	56	0	44	0
J97156	7	100	100	71	43	0	100	100	100	100	100	100	0	86
K97246	9	100	100	100	78	0	100	100	100	89	100	100	0	0
L98152	8	0	100	88	13	0	100	0	25	100	0	100	25	75
T98108	10	100	100	80	70	0	100	100	100	40	100	30	0	100
J98071	6	100	33	67	83	100	0	100	100	100	17	100	0	67

^aPercent prevalence of each PNG within the quasispecies. Sites that differ significantly from the inoculum are shown in bold (Fisher's exact P value, <0.05).

^bTen proviral clones were sequenced from each animal. Duplicate or missense sequences were removed from analysis. N, number of unique clones incorporated for analysis from each animal.

^cProviral clones from the PBMCs used to grow the viral stock of SHIV-89.6P were analyzed as a measure of heterogeneity in the inoculum.