Table 2.
Significant white matter regions for DTI-FA, FW-FA DTI-MD, and FW-MD metrics.
| Voxels | p-value | MNI | Voxels | p-value | MNI | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | X | Y | Z | |||||
| JHU-ICBM-DTI-81 WM Atlas | DTI-FA | FW-FA | ||||||||
| Fornix (column and body of fornix) | 1 | 0.04 | 2 | -4 | 9 | |||||
| Cerebral peduncle R | 37 | 0.001 | 20 | −14 | −5 | |||||
| Anterior corona radiata R | 48 | 0.007 | 20 | −17 | 40 | |||||
| Superior corona radiata R | 2 | 0.04 | 20 | −17 | 39 | 5 | 0.004 | 25 | −18 | 37 |
| Superior corona radiata L | 1 | 0.04 | −22 | −20 | 38 | |||||
| Posterior limb of internal capsule R | 2 | 0.012 | 20 | −14 | −2 | |||||
| Posterior limb of internal capsule L | 20 | 0.001 | −20 | −15 | −4 | |||||
| JHU-ICBM-DTI-81 WM atlas | DTI-MD | FW-MD | ||||||||
| Anterior corona radiata L | 1 | 0.024 | −24 | 27 | 23 | |||||
| Superior corona radiata R | 11 | 0.006 | 19 | −1 | 41 | 3 | 0.001 | 19 | −4 | 42 |
| Superior corona radiata L | 11 | 0.001 | −26 | −16 | 31 | 11 | 0.001 | −26 | −12 | 35 |
| Posterior corona radiata R | 2 | 0.029 | 25 | −24 | 25 | |||||
| Posterior limb of internal capsule L | 1 | 0.013 | −23 | −10 | 15 | |||||
| Cingulum (cingulate gyrus) L | 2 | 0.023 | −8 | −2 | 33 | |||||
| Body of corpus callosum | 1 | 0.017 | −11 | −5 | 35 | |||||
All reported clusters survived correction for multiple comparisons at the voxel level (p < 0.05), with cluster sizes ≥1 voxel.
FA = fractional anisotropy; MD = mean diffusivity; DTI = diffusion tensor imaging; FW-DTI = free-water-corrected diffusion tensor imaging; FW-FA = free-water-corrected fractional anisotropy; FW-MD = free-water-corrected mean diffusivity; R = right; L = left. JHU-ICBM-DTI-81 WM atlas = Johns Hopkins University International Consortium for Brain Mapping DTI-81 white matter atlas.